Ovarian epithelial dysplasia after ovulation induction: time and dose effects

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Ovarian epithelial dysplasia after ovulation induction: time and dose effects.

BACKGROUND Ovarian epithelial dysplasia was first described after prophylactic oophorectomies for genetic risk. Ovarian stimulation has been considered as a risk factor of ovarian cancer by Fathalla's incessant ovulation theory. In this study, we have investigated the risk of ovarian dysplasia after ovulation induction. METHODS We reviewed 99 oophorectomies or cystectomies between 1990 and 20...

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Ovarian Heterotopic Pregnancy after Ovulation Induction with Clomiphene Citrate

Background: An ovarian heterotopic pregnancy is a rare entity associated with life-threatening consequences in case of delayed diagnosis. Case: A 33-year-old nulliparous woman with idiopathic primary infertility underwent a cycle of ovulation induction using Clomiphene Citrate and intrauterine insemination. Although the patient was asymptomatic, the ultrasound demonstrated a missed abortion wit...

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The Use of High Dose Letrozole in Ovulation Induction and Controlled Ovarian Hyperstimulation

Letrozole, an aromatase inhibitor, has been demonstrated to be effective as an ovulation induction and controlled ovarian hyperstimulation agent. However, dose administration has generally been limited to 5 days at 2.5 to 7.5 mg daily. We undertook a retrospective review of over 900 treatment cycles using letrozole in doses as high as 12.5 mg per day. Results indicate that such doses do indeed ...

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Ovulation induction and ovarian cancer: is there a link?

Ovarian cancer accounts for approximately 4% of all cancers occurring in women and ranks the fourth most frequent cause of cancer-related death in women. Despite aggressive treatment modalities the 5 year survival rate remains less than 30%'. Almost 2.5% of all live births/ year result from assisted reproductive techniques (ARD2. Concern has been expressed that exposure to fertility drugs (FD) ...

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Ovulation induction and ovarian tumours: the debate continues.

OBJECTIVE To critically review the published literature regarding the proposed association of ovarian stimulation and increased risk of ovarian tumors. DESIGN A medline search (1966-1997) was done to identify case reports and epidemiological studies relevant to the issue in question. Review articles and critical reappraisals in the form of comments on studies done were also used. RESULTS Va...

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 2008

ISSN: 0268-1161,1460-2350

DOI: 10.1093/humrep/den358